Modelling Parkinson disease
نویسندگان
چکیده
منابع مشابه
Successes of Modelling Parkinson Disease in Drosophila
Over one hundred years of innovative experimentation with the “common fruit fly” or Drosophila melanogaster has placed this remarkable organism at the forefront of contemporary biological research. Whether we consider the implications of modern genetic technologies and comprehensive genomic research, or we are interested in leading-edge aspects of molecular and cellular biology or complex devel...
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BACKGROUND Gaucher disease (GD) is an inborn error of metabolism caused by mutations in the gene (GBA) coding for glucocerebrosidase (GCase), inherited in an autosomal recessive pattern. GD patients have up to 9% risk of developing PD. CASE PRESENTATION We report two patients with GD that developed PD at different disease stages. CONCLUSION We reviewed the literature on the coexistence of P...
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OBJECTIVE To examine whether vagotomy decreases the risk of Parkinson disease (PD). METHODS Using data from nationwide Swedish registers, we conducted a matched-cohort study of 9,430 vagotomized patients (3,445 truncal and 5,978 selective) identified between 1970 and 2010 and 377,200 reference individuals from the general population individually matched to vagotomized patients by sex and year...
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Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder second to Alzheimer’s disease, affecting 1-2% of individuals over 60 years of age, with a risk that increases with age. Its phenotypic complexity, characterized by motor (resting tremor, bradikinesia, rigidity and postural instability) and non-motor (autonomic dysfunction and cognitive impairment) symptoms...
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Parkinson disease (PD) is a progressive, neurodegenerative movement disorder. PD was originally attributed to neuronal loss within the substantia nigra pars compacta, and a concomitant loss of dopamine. PD is now thought to be a multisystem disorder that involves not only the dopaminergic system, but other neurotransmitter systems whose role may become more prominent as the disease progresses (...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2020
ISSN: 1471-003X,1471-0048
DOI: 10.1038/s41583-020-0273-7